Bi-Est+ Topical Replenishing Serum is a nanoemulsified, topical serum providing 0.5 mg of bioidentical estriol (E3) and 0.125 mg of bioidentical estradiol (E2) per 1 pump serving. The estriol and estradiol used to make up this formula originate from diosgenin, a phytosteroid extracted from soy. Bi-Est+ is delivered using proprietary lipid nanoparticle technology for enhanced absorption compared to conventional creams.*

Our patent-pending Quicksilver Delivery Systems^® improves upon liposomal and emulsification technology with smaller, more stable particles made from the highest grade ingredients available.† Our nanoformulated BI-EST Topical Replenishing Serum delivers fast and enhanced absorption of Estriol and Estradiol bypassing liver metabolism for optimal effects.*